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Your Journey to a Healthy Pregnancy

In Vitro Fertilization with Genetic Testing: PGT & PGT-A Plus (PIMS)

From genetic health to developmental potential—understanding your options for a successful pregnancy.

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Introduction:

Precision in Your IVF Journey

Selecting the embryo with the best chance of becoming a healthy baby is the goal of modern IVF. At Vitalisssima Fertility Solutions, we offer a suite of advanced screening technologies to provide you with critical insights. This page will help you understand the differences between Preimplantation Genetic Testing (PGT) and the innovative Pre-Implantation Methylation Screening (PIMS), so you can make a confident, informed choice.

Preimplantation Genetic Testing (PGT):

Screening for Genetic Health

PGT (preimplantation genetic testing) is performed on embryos before transfer. It helps identify embryos with specific genetic or chromosomal conditions.

The Three Types of PGT

We offer three distinct types of PGT, each designed for a different purpose:

PGT-A (Aneuploidy Screening)
  • What it tests for: The overall chromosomal number (Copy Number Variations). It screens for missing or extra chromosomes, a condition known as aneuploidy.
  • Its purpose: To select embryos with the correct number of chromosomes, which significantly reduces the risk of miscarriage and increases implantation success. This is the most common form of PGT.
  • Who it's for:
    • Women of advanced maternal age (35+).
    • Patients with a history of recurrent miscarriage.
    • Those with previous failed IVF cycles.
PGT-M (Monogenic/Single Gene Disorders)

  • What it tests for: Specific, known genetic mutations that parents may carry, such as Cystic Fibrosis, Huntington's disease, or Sickle Cell Anemia.
  • Its purpose: To identify embryos that are unaffected by the specific hereditary condition in question.
  • Who it's for: Couples who are known carriers of the same inherited single-gene disorder.
PGT-SR (Structural Rearrangements)
  • What it tests for: Chromosomal structural errors, such as balanced translocations, where parts of chromosomes have been rearranged.
  • Its purpose: To prevent the transfer of embryos with an unbalanced form of the translocation, which can lead to miscarriage or the birth of a child with health issues.
  • Who it's for: Individuals who are carriers of a chromosomal rearrangement.

PIMS: A Multi-Dimensional View of Embryo Potential

Pre-Implantation Methylation Screening (PIMS) represents a significant leap beyond traditional genetic screening. While PGT analyzes the DNA sequence itself, PIMS delves into the realm of epigenetics—the system of chemical markers that regulate how genes are expressed. This provides a revolutionary, multi-faceted assessment of an embryo’s developmental potential select embryo for implantation, and thus promote the birth rates.

How PIMS Works: Three Layers of Insight in One Test

PIMS utilizes a proprietary single-cell genome methylation sequencing method, combined with advanced AI analysis, to evaluate three critical aspects of embryo health simultaneously

Copy Number Variation (CNV) Detection:
  • What it is: Precisely screens all chromosomes for missing or extra pieces, identifying aneuploidy—just like PGT-A.
  • The Benefit: Ensures the embryo has the correct basic genetic blueprint.
Genome-Wide Methylation Analysis:
  • What it is: Maps the embryo's DNA methylation patterns. Methylation is a key epigenetic "switch" that controls gene activity and is crucial for healthy fetal development.
  • The Benefit: Assesses the embryo's biological readiness for implantation and development, going beyond simple chromosome counting.
Epigenetic Disease Detection:
  • What it is: Specifically screens for imprinting disorders (such as Angelman or Prader-Willi syndromes), which are caused by errors in epigenetic markers rather than the DNA code itself.
  • The Benefit: Adds a unique layer of protection against certain genetic diseases that standard PGT cannot detect.

By integrating these three data streams, our AI algorithm generates a comprehensive viability score, identifying the embryo with the highest overall developmental potential.

The Key Advantages of Choosing PIMS
The Key Advantages of Choosing PIMS
  • Unprecedented Comprehensiveness: PIMS is the only test that combines genetic (CNV) and epigenetic (methylation) analysis for a holistic view of embryo health.
  • Enhanced Clinical Outcomes: This multi-faceted approach is designed to:
    • Promote Live Birth Rates by selecting the embryo with the best implantation potential.
    • Reduce Birth Defect Risks by screening for both chromosomal abnormalities and specific epigenetic disorders.
  • Superior Technical Accuracy:
    • High Resolution: Detection accuracy reaches 1Mb, allowing for the identification of very small chromosomal segments that may be missed by other methods.
    • High Coverage: Provides complete analysis across all chromosomes, leaving no blind spots
Superior Technical Accuracy:
  • What it is: Maps the embryo's DNA methylation patterns. Methylation is a key epigenetic "switch" that controls gene activity and is crucial for healthy fetal development.
  • The Benefit: Assesses the embryo's biological readiness for implantation and development, going beyond simple chromosome counting.
Epigenetic Disease Detection:
  • What it is: Specifically screens for imprinting disorders (such as Angelman or Prader-Willi syndromes), which are caused by errors in epigenetic markers rather than the DNA code itself.
  • The Benefit: Adds a unique layer of protection against certain genetic diseases that standard PGT cannot detect.

Who is PIMS For?

Patients seeking

Patients seeking the most comprehensive and advanced embryo screening available.

Couples

Couples interested in adding a layer of screening for epigenetic imprinting disorders.

Experienced

Those who have experienced prior implantation failure, even with PGT-tested embryos.

Leverage multi-dimensional data

Anyone wanting to leverage multi-dimensional data and AI to maximize their chance of a single-transfer success.

As PIMS is a next-generation technology not yet widely available, choosing Vitalissima Fertility Solutions provides you with exclusive access to this powerful tool within our integrated network of partner clinics.

The PGT and PIMS Process

IVF & Blastocyst Culture

Embryos are created via IVF and cultured to the blastocyst stage (Day 5/6).

Trophectoderm Biopsy

A few cells are safely and gently removed from each embryo.

Genetic Analysis (PGT)

The biopsied cells are analyzed for the specific condition (Aneuploidy, Monogenic, or Structural)；

Advanced Sequencing & AI Analysis (PIMS)

The sample undergoes single-cell genome methylation sequencing. The CNV, methylation, and imprinting data are integrated and analyzed by our proprietary AI algorithm

Embryo Ranking & Selection

You receive a detailed report ranking embryos based on their composite developmental potential, guiding the selection of the single best embryo for frozen embryo transfer (FET).

Embryo Transfer & Storage

A medical catheter icon (for transfer) and a storage tank icon (for cryopreservation).

IVF Plus PGT Cycle

IVF+PGT
Cycle

1
Consultation and analytics/tests
2
Stimulation and egg retrieval (12-15 days)
3
Embryo cultivation and genetic testing
4
Cryopreservation and vitrification of embryos
5
Endometrial preparation and embryo transfer

PGT vs. PIMS: Choosing Your Path

Feature PGT (A, M, SR) PIMS
Analysis Type
Genetic Only: Focuses on the DNA sequence and chromosome number/structure.
Genetic + Epigenetic: Analyzes chromosomes, gene regulation (methylation), and imprinting disorders.
Primary Function
Diagnosis & Exclusion: Identifies and filters out embryos with specific genetic errors.
Potential Assessment & Selection: Ranks all embryos based on a holistic view of their developmental potential.
Disease Screening
Chromosomal Disorders (PGT-A), Single Gene Disorders (PGT-M), Structural Rearrangements (PGT-SR).
Chromosomal Disorders (CNV) + Epigenetic Imprinting Disorders.
Best For
Preventing the transfer of embryos with a known, specific genetic issue.
Identifying the single most viable embryo for transfer, providing the most comprehensive pre-implantation screening available.

In summary: PGT is a targeted filter for genetic abnormalities. PIMS is a comprehensive evaluator of overall embryonic health and developmental potential.

Access This Innovative Technology with Vitalissima

While Pre-Implantation Methylation Screening (PIMS) represents a significant advancement in embryo selection, its availability remains exclusive. The technology is established and clinically available, but it is not yet offerred at every IVF clinic.You have a choice to be a passive patient in the IVF process, or an active, empowered partner in creating a healthy pregnancy. We invite you to choose the latter.
Consultation
The Tangible Benefits

This is where Vitalissima Fertility Solutions provides a distinct advantage.

We have proactively partnered with the providers of PIMS to integrate this powerful technology directly into our clients’ care pathways. When you choose Vitalissima, you are not just choosing a service; you are gaining privileged access to a comprehensive screening tool that remains beyond the reach of most standard clinics.

We bridge the gap, ensuring you can leverage this multi-dimensional analysis within our network of partner IVF centers. It is a core part of our commitment to providing not just holistic support, but also the most sophisticated scientific tools to maximize your chance of a successful pregnancy.

Free Consultation

Ready to leverage our exclusive access to PIMS?

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